Vatsvagiri vakaona kuti iyo yekutanga metabolite yeTHC inoramba ine simba zvichibva pane data kubva kumamodheru mhando. Itsva yetsvagiridzo data inoratidza kuti iyo huru THC metabolite inorambira muweti neropa inogona kunge ichiri kushanda uye inoshanda seTHC, kana zvisiri izvo. Ichi chitsva chinowanikwa chinomutsa mibvunzo yakawanda kupfuura yainopindura. Zvinoenderana neongororo ichangoburwa yakaburitswa mu Journal of Pharmacology uye Experimental Therapeutics, iyo psychoactive metabolite yeTHC, 11-hydroxy-THC (11-OH-THC), ine yakaenzana kana yakakura psychoactive potency kupfuura THC (Delta-9 THC).
Chidzidzo ichi, chakanzi "The Intoxication Equivalence ye11-Hydroxy-Delta-9-THC (11-OH-THC) Inoenderana neDelta-9-THC," inoratidza kuti THC metabolites inochengeta sei basa. Zvinonyatsozivikanwa kuti THC inoputsika uye inogadzira makomisheni matsva anokatyamadza painobvisa uye kuita mumuviri wemunhu. "Muchidzidzo ichi, takaona kuti iyo yekutanga metabolite yeTHC, 11-OH-THC, inoratidza basa rakaenzana kana rakakura kupfuura THC mune mbeva cannabinoid chiitiko modhi painotungamirwa zvakananga, kunyangwe tichifunga mutsauko munzira dzekutonga, zvepabonde, pharmacokinetics, uye pharmacodynamics," chidzidzo chinodaro. "Idzi dhata dzinopa ruzivo rwakakosha muchiitiko chebiological cheTHC metabolites, zivisa ramangwana cannabinoid tsvakiridzo, uye moenzanisira kuti THC kudya uye metabolism zvinokanganisa sei kushandiswa kwevanhu cannabis."
Iyi tsvakurudzo yakaitwa neboka reSaskatchewan, Canada, kusanganisira Ayat Zagzoog, Kenzie Halter, Alayna M. Jones, Nicole Bannatyne, Joshua Cline, Alexis Wilcox, Anna-Maria Smolyakova, naRobert B. Laprairie. Mukuyedza, vaongorori vakabaya mbeva dzechirume ne11-hydroxy-THC uye vakacherekedza uye vakadzidza mhedzisiro yeTHC iyi metabolite kana ichienzaniswa neyakaumbwa yemubereki, Delta-9 THC.
Vatsvakurudzi vakaenderera mberi vachiti: "Idzi data dzinoratidza kuti mumuswe-flick muedzo wekuona marwadzo, basa re11-OH-THC i153% yeTHC, uye mukuongorora kwecatalepsy, basa re11-OH-THC ndeye 78% iyo yeTHC. THC."
Nekudaro, chidzidzo chinoratidza kuti THC metabolite 11-OH-THC inogona kuita basa rakakosha mukuita kwebiological chiitiko che cannabis. Kunzwisisa basa rayo kana raitwa zvakananga kuchabatsira kutsanangura ramangwana remhuka uye zvidzidzo zvevanhu. Chirevo chinotaura kuti 11-OH-THC ndeimwe yematabolites maviri ekutanga akaumbwa mushure mekushandisa cannabis, imwe yacho iri 11-nor-9-carboxy-THC, iyo isiri psychoactive asi inogona kuramba iri muropa kana weti kwenguva yakareba.
Sekureva kweUS Centers for Disease Control and Prevention (CDC), kutanga kuma1980, bvunzo dzeweti dzainyanya kunanga 11-nor-delta-9-THC-9-carboxylic acid (9-carboxy-THC), metabolite yeDelta-9-THC, inova ndiyo inonyanya kushanda mu cannabis.
Chirevo chinonongedza kuti kunyangwe kuputa cannabis kunowanzo gadzira mhedzisiro nekukurumidza kupfuura kushandisa cannabis edibles, huwandu hwe11-OH-THC hunogadzirwa kuburikidza nekudya hwakakura kupfuura kubva mukuputa maruva ecannabis. Chirevo chinoratidza kuti ichi ndicho chimwe chikonzero nei cannabis-yakapinzwa chikafu ichigona kuwedzera psychoactive uye kukonzera nyonganiso kune vasina kugadzirira.
THC Metabolites uye Kuedzwa Kwezvinodhaka
Humbowo hunoratidza kuti cannabis inobata vashandisi zvakasiyana zvichienderana nenzira yekutonga. Chidzidzo che2021 chakaburitswa muPermanent Journal chakaratidza kuti mhedzisiro yekudya cannabis inodyiwa yakakura pane iyo yekuputa cannabis nekuda kwemasabolism ye11-OH-THC.
"Iyo bioavailability yeTHC kuburikidza nevaporization i10% kusvika 35%," vakatsvaga vakanyora. "Mushure mekutora, THC inopinda muchiropa, uko yakawanda yacho inobviswa kana kushandiswa mu 11-OH-THC kana 11-COOH-THC, pamwe neTHC yakasara uye metabolites yayo inopinda muropa. Kuburikidza nemuromo kunwa, bioavailability yeTHC inongova 4% kusvika ku12% mafuta, philicity inokurumidza kutorwa neTHC. Kazhinji, hafu yeupenyu yeplasma yeTHC mune dzimwe nguva vashandisi izuva 1 kusvika ku3, nepo muvashandisi vasingaperi, inogona kureba semazuva mashanu kusvika gumi nematatu.
Zvidzidzo zvinoratidza kuti nguva refu mushure mekunge psychoactive mhedzisiro ye cannabis yapera, THC metabolites senge 11-OH-THC inogona kuramba iri muropa uye weti kwenguva yakareba. Izvi zvinounza matambudziko kune akajairwa nzira dzekuyedza kana vatyairi nevamhanyi vakakanganiswa nekuda kwekushandisa cannabis. Semuyenzaniso, vaongorori vekuAustralia vanga vachiedza kuona nguva yenguva iyo cannabis inogona kukanganisa kutyaira. Mune chimwe chiitiko, Thomas R. Arkell, Danielle McCartney, naIain S. McGregor kubva kuLambert Initiative paYunivhesiti yeSydney vakadzidza kukanganisa kwe cannabis pakukwanisa kutyaira. Chikwata chakaona kuti cannabis inokanganisa kugona kutyaira kwemaawa akati wandei mushure mekuputa, asi kukanganisa uku kunopera THC metabolites isati yabviswa muropa, nemametabolites achiramba ari mumuviri kwemavhiki kana mwedzi.
"Varwere vanoshandisa zvigadzirwa zvine THC vanofanirwa kudzivirira kutyaira uye mamwe mabasa anoona nezvekuchengetedza (semuenzaniso, kushandisa michina), kunyanya panguva yekutanga kurapwa uye kwemaawa akati wandei mushure medoro rega rega," vanyori vakanyora. "Kunyangwe kana varwere vasinganzwe kunge vakaremara, vanogona kuyedza kuti vane THC." Uyezve, varwere vecannabis vekurapa parizvino havabvisirwe panzira yekuongorora zvinodhaka uye zvirango zvine chekuita nemutemo."
Iyi tsvagiridzo nyowani pa11-OH-THC inoratidza kuti zvimwe zvidzidzo zvinodiwa kuti unzwisise zvakadzama kuti THC metabolites inokanganisa sei muviri wemunhu. Kuburikidza chete nekuenderera mberi nekuedza tinogona kuburitsa zvizere zvakavanzika zveaya akasiyana makomisheni.
Nguva yekutumira: Mar-21-2025