THC, CBD, cannabinoids, psychoactive mhedzisiro - iwe unogona kunge wakambonzwa mashoma emazwi aya kana wanga uchiedza kunzwisisa THC, CBD, uye mutsauko uripo. Pamwe iwe wakasanganawo ne endocannabinoid system, cannabinoid receptors, uye kunyange terpenes. Asi chii chaizvo chiri pamusoro?
Kana iwe uchitsvaga nzira yekunzwisisa kuti sei THC zvigadzirwa zvichikukwidza uye zvigadzirwa zveCBD zvisingaite uye zvavanofanira kuita ne endocannabinoids, unogamuchirwa, uri munzvimbo chaiyo.
Cannabinoids uye basa reECS
Kuti unzwisise THC vs CBD uye kuti zvinotikanganisa sei, iwe unofanira kutanga wanzwisisa endocannabinoid system (ECS), iyo inobatsira muviri kuchengetedza kushanda kwehutano kuburikidza nezvikamu zvayo zvitatu zvikuru: "mutumwa" mamorekuru, kana endocannabinoids, iyo miviri yedu inobereka; ma-receptors aya mamorekuru anosunga kune; uye ma enzyme anoaputsa.
Marwadzo, kushushikana, chido chekudya, simba remetabolism, basa remoyo, mubairo uye kukurudzira, kubereka, uye kurara angori mashoma emabasa emuviri ayo cannabinoids maitiro nekuita paECS. Izvo zvingangobatsira zvehutano zve cannabinoids zvakawanda uye zvinosanganisira kuderedza kuzvimba uye kudzora kusvotwa.
Izvo THC inoita
Iyo yakanyanya kuwanda uye inozivikanwa kwazvo cannabinoid inowanikwa mune cannabis chirimwa ndeye tetrahydrocannabinol (THC). Inomutsa CB1 receptor, chikamu cheECS muuropi chinotonga kudhakwa. THC kudhakwa kwakaratidza kuwedzera kuyerera kweropa kune prefrontal cortex, dunhu rehuropi rine mutoro wekuita sarudzo, kutarisisa, hunyanzvi hwemotokari, uye mamwe mabasa epamusoro. Mamiriro chaiwo emhedzisiro yeTHC pane aya mabasa anosiyana kubva kumunhu kuenda kumunhu.
Kana THC ichisunga kune CB1 receptors, zvinokonzeresa manzwiro euphoria kubva kuuropi mubairo system. Cannabis inomutsa nzira yemubairo wehuropi, inoita kuti tinzwe zvakanaka, uye inowedzera mukana wedu wekutora zvakare mune ramangwana. Mhedzisiro yeTHC pahurongwa hwemubairo wehuropi chinhu chikuru mukukwanisa kwecannabis kuburitsa manzwiro ekudhakwa uye kufara.
Chii chinoita CBD
THC iri kure neiyo chete inongedzo mune cannabis ine yakananga kukanganisa kushanda kwehuropi. Kuenzanisa kunonyanya kukosha ndeye cannabidiol (CBD), inova yechipiri yakanyanya kuwanda cannabinoid inowanikwa muchirimwa che cannabis. CBD inowanzonzi isiri-psychoactive asi izvi zvinorasisa sezvo chero chinhu chine chekuita nekushanda kwehuropi chiri psychoactive. CBD inonyatso inogadzira psychoactive mhedzisiro kana ichidyidzana nehuropi uye nechepakati tsinga sisitimu, sezvo ichinzi ine yakasimba kwazvo anti-seizure uye anti-kufunganya zvivakwa.
Saka nepo CBD ichinyatso psychoactive, haina kudhakisa. Kureva kuti hazvikukwidzi. Imhaka yekuti CBD yakashata zvakanyanya pakuisa iyo CB1 receptor. Muchokwadi, humbowo hunoratidza kuti zvinokanganisa basa reCB1 receptor, kunyanya pamberi peTHC. Kana THC neCBD zvichishanda pamwechete kukanganisa CB1 receptor chiitiko, vashandisi vanowanzonzwa kunyorova, nuanced yakakwirira uye vane mukana wakaderera wekusangana neparanoia zvichienzaniswa nemhedzisiro inonzwika kana CBD isipo. Imhaka yekuti THC inomisa iyo CB1 receptor, nepo CBD ichiirambidza.
Maitiro eCBD neTHC anodyidzana sei
Zvichitaurwa zviri nyore, CBD inogona kudzivirira kubva mukukanganisa kwekuziva kwakabatana nekunyanya kuratidzwa kune THC. Chidzidzo che2013 chakaburitswa muJournal of Psychopharmacology yakapihwa THC kune vatori vechikamu uye yakaona kuti avo vakapihwa CBD pamberi peiyo THC manejimendi vakaratidza kushoma episodic memory impairment kupfuura varwere vakapihwa placebo - zvichiratidza kuti CBD inogona kudzikamisa THC-induced cognitive. deficits.
Asi izvo, ongororo ya2013 yezvidzidzo zvinoda kusvika chiuru nemazana matatu zvakaburitswa mumagazini esainzi zvakaona kuti "CBD inogona kurwisa zvakaipa zveTHC." Ongororo iyi zvakare inonongedza kudiwa kwekuwedzera kutsvagisa uye kutarisa kweCBD mhedzisiro paTHC kushandiswa mune chaiyo-yepasirese mamiriro. Asi iyo data iripo yakajeka zvakakwana kuti CBD inowanzokurudzirwa semushonga kune avo vakashandisa yakawandisa THC nekusaziva uye vanozviwana varemerwa.
Cannabinoids inodyidzana neakawanda masisitimu mumuviri
THC uye CBD inosunga kune akati wandei zvimwe zvinangwa mumuviri. CBD, semuenzaniso, ine angangoita gumi nemaviri nzvimbo dzekuita muuropi. Uye uko CBD inogona kuenzanisa mhedzisiro yeTHC kuburikidza nekuvharira CB1 receptors, inogona kuve nemimwe mhedzisiro paTHC metabolism munzvimbo dzakasiyana dzekuita.
Nekuda kweizvozvo, CBD inogona kusagara ichirambidza kana kuenzanisa mhedzisiro yeTHC. Inogona zvakare kusimudzira zvakananga THC's inogona kunaka mabhenefiti ekurapa. CBD inogona, semuenzaniso, kuwedzera THC-induced marwadzo. THC inogona kunge iri yese anti-kuzvimba uye neuroprotective antioxidant, zvakanyanya nekuda kwekuita kwayo kweCB1 receptors munzvimbo yehuropi-inodzora marwadzo.
Chidzidzo kubva ku2012 chakaratidza kuti CBD inodyidzana nealpha-3 (α3) glycine receptors, chinangwa chakakosha chekurwadziwa mumusana, kudzvinyirira kurwadziwa kusingaperi uye kuzvimba. Iwo muenzaniso weinonzi entourage athari, umo akasiyana cannabis makomisheni anoshanda pamwechete sese kuti abudise mhedzisiro yakakura kupfuura kana yakadyiwa zvakasiyana.
Asi kunyange kudyidzana uku hakuna kunyatsojeka. Muchidzidzo chaFebruary 2019, vaongorori vakawana kuti yakaderera madhasi eCBD akanyatso wedzera kudhakisa mhedzisiro yeTHC, ukuwo madhasi akakwira eCBD akaderedza kudhaka kweTHC.
Terpenes uye etourage effect
Zvinogoneka chose kuti mamwe ecannabis 'anonyanya kuzivikanwa mhedzisiro (senge sofa-kukiya) anogona kunge aine zvishoma zvekuita neTHC pachayo, asi pane kudaro, mipiro yehukama yemamorekuru anozivikanwa. Makemikari anosanganisirwa anonzi terpenes anopa cannabis zvidyarwa zvakasarudzika zvinonaka uye kunhuhwirira. Zvinowanikwa mumiti yakawanda - selavender, bark yemuti, uye hops - uye inopa kunhuhwirira kwemafuta anokosha. Terpenes, rinova iro boka rakakura kwazvo rezvinozivikanwa phytochemicals mu cannabis, zvakare yakaratidza kuve chikamu chakakosha cheiyo entourage mhedzisiro. Kwete chete kuti terpenes inopa cannabis kunhuhwirira kwakasiyana uye kunhuhwirira, asi zvakare inoratidzika kunge inotsigira mamwe cannabis mamorekuru mukugadzira physiological uye cerebral mhedzisiro.
Pazasi mutsetse
Cannabis chirimwa chakaoma chine tsvakiridzo shoma inowanikwa mumhedzisiro yayo uye kudyidzana nemuviri wemunhu - uye isu tiri kutanga kudzidza nzira dzakawanda THC, CBD, uye mamwe makomisheni e cannabis anoshanda pamwe chete uye anodyidzana neECS yedu kuchinja maitiro. nzira yatinonzwa nayo.
Nguva yekutumira: Oct-19-2021